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CS-W001157 4
Total: USD 88.00

6-Bromobenzo[d]isoxazole-3-carboxylic acid

  • CAS No. 1123169-17-4

  • Cat. No. CS-0103843
  • Purity≥97%
  • MDL No.MFCD09027541
  • HazMat Fee +

    HazMat Fee

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

6-Bromobenzo[d]isoxazole-3-carboxylic acid|CS-0103843

Structure of 1123169-17-4

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Description

6-Bromobenzo[d]isoxazole-3-carboxylic acid integrates a bromine substituent and carboxylic acid group into a fused isoxazole scaffold, offering a versatile platform for cross-coupling reactions and bioconjugation. The electron-deficient heterocycle enhances reactivity in palladium-catalyzed transformations, while the carboxylic acid enables direct derivatization or salt formation. This bench-stable compound facilitates rapid access to functionalized pharmaceutical intermediates and materials precursors.

Application

6-Bromobenzo[d]isoxazole-3-carboxylic acid serves as a versatile building block for constructing bioactive heterocycles, enabling palladium-catalyzed cross-coupling reactions due to its stable bromo substituent. The carboxylic acid group facilitates direct derivatization or salt formation, enhancing solubility and purification. Its bench-stable structure supports reliable use in medicinal chemistry workflows, particularly for synthesizing fused isoxazole scaffolds relevant to kinase inhibitors and CNS-targeted compounds.

General Information

  • CAS No. 1123169-17-4
  • Cat. No. CS-0103843
  • Purity ≥97%
  • MDL No. MFCD09027541
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₄BrNO₃
  • Molecular Weight 242.03
  • Synonym(s) 6-Bromobenzisoxazole-3-carboxylic acid
  • SMILES O=C(C1=NOC2=C1C=CC(Br)=C2)O

Computational Chemistry Data

  • TPSA   63.33
  • LogP   2.2885
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P233-P260-P261-P264-P271-P280-P302+P352-P304+P340-P340-P403-P405-P501

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