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CS-W001157 4
Total: USD 88.00

7-Chloro-1H-indazol-6-amine

  • CAS No. 112635-08-2

  • Cat. No. CS-0060361
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

7-Chloro-1H-indazol-6-amine|CS-0060361

Structure of 112635-08-2

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General Information

  • CAS No. 112635-08-2
  • Cat. No. CS-0060361
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆ClN₃
  • Molecular Weight 167.60
  • Synonym(s) 1H-Indazol-6-amine,7-chloro
  • SMILES C1=CC(=C(C2=NNC=C12)Cl)N

Description

7-Chloro-1H-indazol-6-amine is a bench-stable heterocyclic amine featuring a chlorine substituent at the 7-position and a primary amine at the 6-position. This electron-deficient scaffold integrates readily into pharmaceutical intermediates, enabling efficient coupling reactions in medicinal chemistry. The para-chloro functionality enhances reactivity in cross-coupling processes, while the indazole core provides structural rigidity and favorable binding interactions.

Application

7-Chloro-1H-indazol-6-amine serves as a versatile building block in medicinal chemistry, enabling efficient construction of bioactive heterocycles. Its electron-deficient indazole core facilitates palladium-catalyzed couplings and nucleophilic substitutions, while the primary amine supports straightforward derivatization. The molecule exhibits good bench stability and compatibility with common protecting group strategies, making it well-suited for iterative synthesis campaigns targeting kinase inhibitors and other pharmaceutical scaffolds.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   54.7
  • LogP   1.7985
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   0

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