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2-(4-Fluorophenyl)propan-2-amine

  • CAS No. 17797-10-3

  • Cat. No. CS-0112273
  • Molecule weight153.20
  • Purity≥96%
  • MDL No.MFCD07777176

*For research and further manufacturing use only, not for direct human use.

2-(4-Fluorophenyl)propan-2-amine|CS-0112273

Structure of 17797-10-3

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General Information

  • CAS No. 17797-10-3
  • Cat. No. CS-0112273
  • Purity ≥96%
  • MDL No. MFCD07777176
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₂FN
  • Molecular Weight 153.20
  • Synonym(s) 1-(4-Fluorophenyl)-1-Methyl-Ethylamine
  • SMILES NC(C)(C1=CC=C(F)C=C1)C

Description

2-(4-Fluorophenyl)propan-2-amine features a sterically hindered tertiary amine core paired with an electron-deficient fluorophenyl group, enabling robust integration into bioactive scaffolds. This bench-stable compound facilitates efficient coupling in medicinal chemistry campaigns, particularly for targeting G protein-coupled receptors and kinase inhibitors.

Application

2-(4-Fluorophenyl)propan-2-amine serves as a valuable building block in medicinal chemistry, enabling the synthesis of biologically active compounds through standard amine functionalization. Its tertiary amine structure offers enhanced metabolic stability and favorable solubility profiles. The molecule exhibits robust bench stability, facilitates straightforward purification, and tolerates a range of reaction conditions, making it ideal for use in coupling reactions, reductive amination, and heterocycle construction within API development workflows.

Synthesis

  • Route1
    • null|null
      1194-02-1
    • null|null
      917-54-4
    • ~92%
    • In-stock
      2-(4-Fluorophenyl)propan-2-amine|CS-0112273
      17797-10-3

    References

    • PHARMACIA and UPJOHN COMPANY LLC Patent: WO2007/20502 A2, 2007 ; Location in patent: Page/Page column 37 ; WO 2007/020502 A2
  • Route2

    References

    • Sankyo Company, Limited Patent: US5536714 A1, 1996 ;
  • Route3
    • null|null
      1000141-64-9
    • ~%
    • In-stock
      2-(4-Fluorophenyl)propan-2-amine|CS-0112273
      17797-10-3

    References

    • Chemistry - A European Journal, , vol. 13, # 33 p. 9207 - 9215

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 1760
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H315-H318-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   2.0195
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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