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Structure of 114745-26-5
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5'-O-Dmt-n2-isobutyryl-2'-O-methyl-D-guanosine features a Dmt-protected 5'-hydroxyl group and a sterically hindered n2-isobutyryl modification, enhancing stability during oligonucleotide synthesis. The 2'-O-methyl substitution confers nuclease resistance and improved binding affinity, making this derivative ideal for antisense applications requiring enhanced metabolic durability and structural fidelity.
5'-O-Dmt-n2-isobutyryl-2'-O-methyl-D-guanosine serves as a key nucleoside building block for the synthesis of modified oligonucleotides, offering enhanced stability and controlled reactivity. The Dmt (dimethoxytrityl) group at the 5'-position enables efficient chain elongation in solid-phase synthesis, while the n2-isobutyryl protection ensures selective guanine base handling. The 2'-O-methyl modification confers nuclease resistance and improved binding affinity, making this derivative valuable for therapeutic RNA applications requiring robust backbone integrity and targeted functionalization.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H320-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: