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Structure of 144089-96-3
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DMT-2'-F-iBu-G delivers a sterically hindered, fluorinated nucleoside building block with enhanced stability and improved coupling efficiency in oligonucleotide synthesis. The 2'-fluoro isobutyl modification confers resistance to nuclease degradation while maintaining favorable hybridization properties. This protected phosphoramidite integrates seamlessly into automated workflows for therapeutic and diagnostic applications.
DMT-2'-F-iBu-G serves as a protected nucleoside building block for the synthesis of modified oligonucleotides, featuring a 2'-fluoro substitution and isobutyl protection at the 3'-oxygen. The dimethoxytrityl (DMT) group enables efficient monitoring and purification during solid-phase synthesis. This derivative offers enhanced nuclease resistance and improved hybridization affinity, facilitating reliable incorporation into antisense and siRNA constructs with minimal side reactions.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: