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Structure of 68892-41-1
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5'-O-DMT-N2-ibu-dG is a protected deoxyguanosine derivative featuring a 5'-O-dimethoxytrityl group and a N2-isobutyryl modification. This combination enhances stability during oligonucleotide synthesis, enabling efficient incorporation into DNA strands with improved solubility and reduced side reactions under standard conditions.
5'-O-DMT-N2-ibu-dG serves as a key building block for the synthesis of oligonucleotides containing modified guanine residues. The DMT group provides robust protection at the 5'-hydroxyl, enabling efficient purification via reverse-phase chromatography. The N2-isobutyryl modification enhances stability and facilitates selective deprotection during solid-phase synthesis. This derivative enables reliable incorporation of functionalized guanine units into DNA strands, supporting applications in antisense technology and nucleic acid therapeutics.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: