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CS-W001157 4
Total: USD 88.00

5-Iodo-2-methyl-2H-indazole

  • CAS No. 1150617-94-9

  • Cat. No. CS-B1048
  • Molecule weight258.06
  • Purity≥97%
  • MDL No.MFCD11977518

*For research and further manufacturing use only, not for direct human use.

5-Iodo-2-methyl-2H-indazole|CS-B1048

Structure of 1150617-94-9

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General Information

  • CAS No. 1150617-94-9
  • Cat. No. CS-B1048
  • Purity ≥97%
  • MDL No. MFCD11977518
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇IN₂
  • Molecular Weight 258.06
  • Synonym(s) 5-iodo-2-methylindazole
  • SMILES CN1N=C2C=CC(I)=CC2=C1

Description

5-Iodo-2-methyl-2H-indazole is a bench-stable heterocyclic scaffold featuring an iodinated indazole core with a methyl group at the 2-position. This configuration enables direct functionalization via cross-coupling reactions, making it ideal for constructing complex pharmaceutical intermediates and bioactive molecules in medicinal chemistry.

Application

5-Iodo-2-methyl-2H-indazole serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions for the construction of biaryl and heteroaryl scaffolds. The iodide group provides high reactivity in Suzuki, Stille, and Negishi couplings, while the 2-methyl substituent enhances stability and modulates electronic properties. Its bench-stable nature and compatibility with diverse functional groups make it ideal for iterative synthesis campaigns targeting complex pharmaceutical intermediates.

Synthesis

  • Route1
    • In-stock
      5-Iodo-1H-indazole|CS-D1249
      55919-82-9
    • null|null
      420-37-1
    • ~67%
    • In-stock
      5-Iodo-2-methyl-2H-indazole|CS-B1048
      1150617-94-9

    References

    • ELI LILLY AND COMPANY Patent: US2012/28984 A1, 2012 ; Location in patent: Page/Page column 3 ; US 20120028984 A1
  • Route2

    References

    • US2012/28984 A1, ; US 20120028984 A1
  • Route3

    References

    • US2012/28984 A1, ; US 20120028984 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   17.82
  • LogP   2.1779
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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