(R)-1,3-Dimethylpiperazine dihydrochloride

Name: (R)-1,3-Dimethylpiperazine dihydrochloride
Brand: ChemScene
Availability: InStock
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CAS No. 1152110-26-3
Cat. No. CS-0067514
Purity≥97%
MDL No.MFCD12913781

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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(R)-1,3-Dimethylpiperazine dihydrochloride|CS-0067514

Structure of 1152110-26-3

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Description

(R)-1,3-Dimethylpiperazine dihydrochloride is a bench-stable chiral amine salt featuring two methyl groups at the 1- and 3-positions of the piperazine ring. This configuration imparts enhanced stereochemical control in asymmetric synthesis, particularly in catalytic transformations and medicinal chemistry applications. The dihydrochloride form improves solubility in aqueous and polar organic media, facilitating use in reaction setups requiring precise protonation states.

Application

(R)-1,3-Dimethylpiperazine dihydrochloride serves as a chiral amine building block in medicinal chemistry, enabling the synthesis of bioactive molecules through standard coupling and functionalization reactions. Its bench-stable, crystalline form facilitates handling and purification, while the piperazine core offers favorable solubility and metabolic stability in drug candidates. Functions effectively in transition-metal-catalyzed cross-couplings and as a scaffold for diversification via alkylation or acylation.

General Information

CAS No. 1152110-26-3
Cat. No. CS-0067514
Purity ≥97%
MDL No. MFCD12913781
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₁₆Cl₂N₂
Molecular Weight 187.11
Synonym(s) 1,3-Dimethylpiperazine dihydrochloride
SMILES C[C@@H]1CN(C)CCN1.[H]Cl.[H]Cl

Computational Chemistry Data

TPSA 15.27
LogP 0.7535
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

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(R)-1,3-Dimethylpiperazine dihydrochloride

CAS No. 1152110-26-3

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