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CS-W001157 4
Total: USD 88.00

4,5-Dichloropyrimidin-2-amine

  • CAS No. 403854-21-7

  • Cat. No. CS-W019048
  • Purity≥95%
  • MDL No.MFCD13193667
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

4,5-Dichloropyrimidin-2-amine|CS-W019048

Structure of 403854-21-7

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Description

4,5-Dichloropyrimidin-2-amine features a dual chloro substitution at the 4- and 5-positions of the pyrimidine ring, imparting enhanced electrophilicity and reactivity. This electron-deficient scaffold integrates readily into heterocyclic architectures, serving as a pivotal building block in medicinal chemistry and agrochemical synthesis. The amine functionality enables straightforward derivatization via coupling reactions.

Application

4,5-Dichloropyrimidin-2-amine serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient construction of heterocyclic scaffolds. Its dual chloro substituents at C4 and C5 facilitate nucleophilic substitution reactions with amines, thiols, and other soft nucleophiles, allowing rapid diversification. The molecule exhibits good bench stability and is compatible with standard purification techniques, making it well-suited for iterative synthesis campaigns and library generation.

General Information

  • CAS No. 403854-21-7
  • Cat. No. CS-W019048
  • Purity ≥95%
  • MDL No. MFCD13193667
  • Storage -20°C, sealed storage, away from moisture and light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₃Cl₂N₃
  • Molecular Weight 163.99
  • Synonym(s) 4,5-Dichloro-pyrimidin-2-ylamine
  • SMILES ClC1=NC(=NC=C1Cl)N

Computational Chemistry Data

  • TPSA   51.8
  • LogP   1.3656
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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