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CS-W001157 4
Total: USD 88.00

5-(Biotinamido)pentylamine

  • CAS No. 115416-38-1

  • Cat. No. CS-0112430
  • Purity≥98%
  • MDL No.MFCD00216002

*For research and further manufacturing use only, not for direct human use.

5-(Biotinamido)pentylamine|CS-0112430

Structure of 115416-38-1

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General Information

  • CAS No. 115416-38-1
  • Cat. No. CS-0112430
  • Purity ≥98%
  • MDL No. MFCD00216002
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₅H₂₈N₄O₂S
  • Molecular Weight 328.47
  • Synonym(s) None
  • SMILES O=C(NCCCCCN)CCCC[C@@H]1SC[C@]([C@]1([H])N2)([H])NC2=O

Description

5-(Biotinamido)pentylamine is a bifunctional linker featuring a biotin moiety linked via a five-atom aliphatic chain to a primary amine. This structure enables efficient conjugation to biomolecules through amine-reactive chemistries while retaining high-affinity binding to streptavidin and avidin. The flexible spacer minimizes steric interference in labeling applications, supporting robust detection or immobilization in assays, pull-down experiments, and bioconjugation workflows.

Application

5-(Biotinamido)pentylamine serves as a versatile bifunctional linker for bioconjugation, enabling site-specific attachment of biotin to proteins, antibodies, or oligonucleotides via amide bond formation. The primary amine facilitates conjugation under standard coupling conditions, while the biotin moiety provides high-affinity binding to streptavidin or avidin. Its stability and compatibility with aqueous buffers make it ideal for immunoassays, pull-down assays, and affinity purification workflows.

Synthesis

  • Route1
    • null|null
      328273-17-2
    • ~91%
    • In-stock
      5-(Biotinamido)pentylamine|CS-0112430
      115416-38-1

    References

    • ASTRAZENECA AB; UNIVERSITY OF CHICAGO Patent: WO2006/65218 A1, 2006 ; Location in patent: Page/Page column 16 ; WO 2006/065218 A1
  • Route2

    References

    • Cheng, Ting-Jen R.; Wang, Shi-Yun; Wen, Wen-Hsien; Su, Ching-Yao; Lin, Mengi; Wen-I Huang; Liu, Ming-Tsan; Wu, Ho-Sheng; Wang, Nung-Sen; Cheng, Chung-Kai; Chen, Chun-Lin; Ren, Chien-Tai; Wu, Chung-Yi; Fang, Jim-Min; Cheng, Yih-Shyun E.; Wong, Chi-Huey Angewandte Chemie - International Edition, 2013 , vol. 52, # 1 p. 366 - 370
  • Route3

    References

    • Tetrahedron, , vol. 56, # 46 p. 9003 - 9014

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362

Quality Control

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Computational Chemistry Data

  • TPSA   96.25
  • LogP   0.9574
  • H_Acceptors   4
  • H_Donors   4
  • Rotatable_Bonds   10

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