1-(1-Boc-4-piperidyl)-2,2,2-trifluoroethylamine

Name: 1-(1-Boc-4-piperidyl)-2,2,2-trifluoroethylamine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 1159982-64-5
Cat. No. CS-0186209
Purity≥97%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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1-(1-Boc-4-piperidyl)-2,2,2-trifluoroethylamine|CS-0186209

Structure of 1159982-64-5

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Description

1-(1-Boc-4-piperidyl)-2,2,2-trifluoroethylamine features a trifluoromethylated ethyl linker that enhances metabolic stability and lipophilicity. The Boc-protected piperidine moiety enables straightforward deprotection for downstream functionalization. This scaffold integrates readily into bioactive molecules requiring electron-deficient alkyl chains and improved membrane permeability under standard conditions.

Application

1-(1-Boc-4-piperidyl)-2,2,2-trifluoroethylamine serves as a versatile building block for the synthesis of bioactive molecules, enabling efficient incorporation of trifluoromethylated piperidine motifs. The Boc-protected amine offers bench stability and orthogonal handling, while the trifluoroethyl group provides enhanced metabolic stability and modulated lipophilicity. It functions effectively in standard coupling reactions and facilitates access to complex heterocyclic scaffolds relevant to medicinal chemistry.

General Information

CAS No. 1159982-64-5
Cat. No. CS-0186209
Purity ≥97%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₂H₂₁F₃N₂O₂
Molecular Weight 282.30
Synonym(s) Tert-butyl 4-(1-amino-2,2,2-trifluoroethyl)piperidine-1-carboxylate
SMILES CC(C)(C)OC(=O)N1CCC(CC1)C(C(F)(F)F)N

Computational Chemistry Data

TPSA 55.56
LogP 2.5231
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Other Classifications

Building Blocks Functional Group Amine

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Key Words

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1-(1-Boc-4-piperidyl)-2,2,2-trifluoroethylamine

CAS No. 1159982-64-5

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