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Structure of 1160246-91-2
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tert-Butyl 3-amino-1-oxa-8-azaspiro[4.5]decane-8-carboxylate is a spirocyclic heterobicyclic scaffold featuring a pendant amino group and a bench-stable tert-butyl ester. This configuration enables direct incorporation into complex molecular architectures, particularly in medicinal chemistry campaigns targeting CNS-active compounds and kinase inhibitors. The rigid, three-dimensional framework enhances metabolic stability and modulates solubility profiles during lead optimization.
tert-Butyl 3-amino-1-oxa-8-azaspiro[4.5]decane-8-carboxylate serves as a versatile spirocyclic scaffold for medicinal chemistry, enabling efficient access to complex heterocycles through standard amine functionalization and coupling reactions. The protected amine and ester groups offer excellent bench stability, orthogonal reactivity, and compatibility with diverse synthetic transformations. Its rigid spiro architecture supports conformational constraint in target molecules, enhancing binding affinity and metabolic stability in lead optimization campaigns.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: