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Structure of 117324-58-0
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Methyl 2-amino-5-(trifluoromethyl)benzoate features a trifluoromethyl group enhancing electron-withdrawal and metabolic stability, paired with a primary amine enabling facile derivatization. This ortho-substituted scaffold integrates readily into pharmaceutical intermediates, offering improved solubility and reactivity under standard conditions.
Methyl 2-amino-5-(trifluoromethyl)benzoate serves as a versatile building block in medicinal chemistry, enabling the synthesis of biologically active heterocycles and pharmaceutical intermediates. Its ortho-amino and trifluoromethyl groups provide complementary reactivity for electrophilic substitution, coupling reactions, and transition-metal-catalyzed transformations. The methyl ester facilitates downstream derivatization, while the molecule exhibits good bench stability and compatibility with standard purification methods.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: