(2-Amino-5-(trifluoromethyl)phenyl)methanol

Name: (2-Amino-5-(trifluoromethyl)phenyl)methanol
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CAS No. 220107-65-3
Cat. No. CS-0097942
Purity≥95%
MDL No.MFCD11849935

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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(2-Amino-5-(trifluoromethyl)phenyl)methanol|CS-0097942

Structure of 220107-65-3

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Description

This bench-stable arylmethanol features a para-trifluoromethyl group and an ortho-amino substituent, delivering enhanced electron-withdrawing character and improved solubility in polar organic solvents. The functionalized scaffold enables direct incorporation into bioactive heterocycles and serves as a key intermediate for pharmaceutical and agrochemical synthesis under standard conditions.

Application

(2-Amino-5-(trifluoromethyl)phenyl)methanol serves as a valuable building block in medicinal chemistry, enabling the synthesis of heterocyclic scaffolds and bioactive molecules. Its ortho-amino and benzylic alcohol functionalities offer orthogonal reactivity for sequential transformations, including coupling reactions, cyclizations, and derivatization. The trifluoromethyl group enhances metabolic stability and lipophilicity, while the compound exhibits good bench stability and ease of purification—making it well-suited for scalable synthetic workflows in API development.

General Information

CAS No. 220107-65-3
Cat. No. CS-0097942
Purity ≥95%
MDL No. MFCD11849935
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₈F₃NO
Molecular Weight 191.15
Synonym(s) 2-Amino-5-(trifluoromethyl)benzyl alcohol
SMILES OCC1=CC(C(F)(F)F)=CC=C1N

Computational Chemistry Data

TPSA 46.25
LogP 1.7799
H_Acceptors 2
H_Donors 2
Rotatable_Bonds 1

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H320-H335
Precautionary Statements : P261-P280-P302+P352

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Other Classifications

Building Blocks Functional Group Alcohol

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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(2-Amino-5-(trifluoromethyl)phenyl)methanol

CAS No. 220107-65-3

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