3-Bromo-1H-pyrazolo[3,4-b]pyridin-5-amine

Name: 3-Bromo-1H-pyrazolo[3,4-b]pyridin-5-amine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 1186608-71-8
Cat. No. CS-0044889
Purity≥98%
MDL No.MFCD13193613

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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3-Bromo-1H-pyrazolo[3,4-b]pyridin-5-amine|CS-0044889

Structure of 1186608-71-8

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Description

3-Bromo-1H-pyrazolo[3,4-b]pyridin-5-amine features a brominated pyrazolopyridine core with a primary amine at the 5-position, enabling direct coupling in cross-coupling reactions. The electron-deficient heterocycle facilitates palladium-catalyzed transformations, while the amine group serves as a handle for further functionalization. This scaffold demonstrates stability under standard reaction conditions and is well-suited for medicinal chemistry campaigns targeting kinase inhibitors and other bioactive molecules.

Application

3-Bromo-1H-pyrazolo[3,4-b]pyridin-5-amine serves as a versatile building block for the synthesis of bioactive heterocycles, enabling palladium-catalyzed cross-coupling reactions due to its stable bromo functionality and electron-deficient pyrazolopyridine core. Its amine group provides a handle for derivatization, while the molecule exhibits good bench stability and compatibility with standard purification techniques, facilitating integration into medicinal chemistry and process development workflows.

General Information

CAS No. 1186608-71-8
Cat. No. CS-0044889
Purity ≥98%
MDL No. MFCD13193613
Storage 4°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₅BrN₄
Molecular Weight 213.03
Synonym(s) None
SMILES NC1=CN=C(NN=C2Br)C2=C1

Computational Chemistry Data

TPSA 67.59
LogP 1.3026
H_Acceptors 3
H_Donors 2
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Building Blocks Skeleton Aromatic heterocycle compounds Pyrazole compounds

Key Words

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3-Bromo-1H-pyrazolo[3,4-b]pyridin-5-amine

CAS No. 1186608-71-8

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