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Structure of 118972-96-6
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1-(3-Hydroxyazetidin-1-yl)ethanone features a strained azetidine ring bearing a hydroxyl group and a ketone-functionalized ethyl linker, enabling direct integration into bioactive scaffolds. This polar, bench-stable moiety facilitates efficient coupling in peptide conjugation and medicinal chemistry campaigns, offering enhanced solubility and metabolic stability compared to analogous acyclic analogs.
1-(3-Hydroxyazetidin-1-yl)ethanone serves as a versatile building block for synthesizing β-lactam-containing scaffolds and bioactive heterocycles. Its azetidinone functionality enables straightforward ring-opening reactions and conjugate additions, while the pendant hydroxyl group offers site-specific derivatization potential. The compound exhibits good bench stability and facilitates efficient purification via standard chromatographic methods, making it well-suited for iterative medicinal chemistry campaigns and process-scale synthesis.
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: