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CS-W001157 4
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3-Hydroxyazetidine

  • CAS No. 45347-82-8

  • Cat. No. CS-0084651
  • Purity≥97%
  • MDL No.MFCD03695446

*For research and further manufacturing use only, not for direct human use.

3-Hydroxyazetidine|CS-0084651

Structure of 45347-82-8

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General Information

  • CAS No. 45347-82-8
  • Cat. No. CS-0084651
  • Purity ≥97%
  • MDL No. MFCD03695446
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃H₇NO
  • Molecular Weight 73.09
  • Synonym(s) Azetidin-3-ol
  • SMILES OC1CNC1

Description

D-(-)-Lactic acid is a useful biochemical for proteomics research. It is also used in the production of chiral drug and in the chemical synthesis. Lactic acid is used as a reagent in organic synthesis (in the manufacture of adhesives). It is used in the leather, textile, and tanning industries. It may be used as a plasticizer, a catalyst, or an acidifying agent. Lactic acid has even been used as a flavoring agent in the manufacture of tobacco products.

Application

3-Hydroxyazetidine serves as a valuable building block in medicinal chemistry, enabling the construction of bioactive heterocycles through well-established functional group transformations. Its constrained ring structure enhances metabolic stability and modulates physicochemical properties, while the hydroxyl group offers direct handle for derivatization via esterification, etherification, or coupling reactions. Bench-stable and compatible with standard synthetic protocols, it facilitates efficient access to diverse azetidinyl scaffolds relevant to drug discovery programs.

Synthesis

  • Route1

    References

    • Falgueyret; Oballa; Okamoto; Wesolowski; Aubin; Rydzewski; Prasit; Riendeau; Rodan; Percival Journal of Medicinal Chemistry, 2001 , vol. 44, # 1 p. 94 - 104
  • Route2

    References

    • Claffey, Michelle M.; Helal, Christopher J.; Verhoest, Patrick R.; Kang, Zhijun; Fors, Kristina S.; Jung, Stanley; Zhong, Jiaying; Bundesmann, Mark W.; Hou, Xinjun; Lui, Shenping; Kleiman, Robin J.; Vanase-Frawley, Michelle; Schmidt, Anne W.; Menniti, Frank; Schmidt, Christopher J.; Hoffman, William E.; Hajos, Mihaly; McDowell, Laura; Oconnor, Rebecca E.; MacDougall-Murphy, Mary; Fonseca, Kari R.; Becker, Stacey L.; Nelson, Frederick R.; Liras, Spiros Journal of Medicinal Chemistry, 2012 , vol. 55, # 21 p. 9055 - 9068
  • Route3
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      111043-42-6
    • ~%
    • In-stock
      3-Hydroxyazetidine|CS-0084651
      45347-82-8

    References

    • PHARMACIA and UPJOHN COMPANY LLC Patent: WO2007/4049 A1, 2007 ; Location in patent: Page/Page column 16-17; 41-42 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3259
Class : 8
Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   32.26
  • LogP   -1.0495
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   0

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