2-Chloro-4-(cyclopropylamino)pyrimidine-5-carboxylic acid

Name: 2-Chloro-4-(cyclopropylamino)pyrimidine-5-carboxylic acid
Brand: ChemScene
Availability: InStock
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CAS No. 1192711-37-7
Cat. No. CS-0035791
Purity≥95%
MDL No.MFCD24499915

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Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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2-Chloro-4-(cyclopropylamino)pyrimidine-5-carboxylic acid|CS-0035791

Structure of 1192711-37-7

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Description

This pyrimidine derivative features a cyclopropylamino group and a carboxylic acid at the 4- and 5-positions, respectively, enabling direct integration into bioactive scaffolds. The electron-deficient pyrimidine core supports efficient coupling reactions under standard conditions, while the carboxylic acid facilitates conjugation without requiring activation.

Application

2-Chloro-4-(cyclopropylamino)pyrimidine-5-carboxylic acid serves as a versatile building block in the synthesis of pyrimidine-based heterocycles, enabling efficient access to medicinally relevant scaffolds. Its functional group array—comprising a chloro substituent, cyclopropylamino handle, and carboxylic acid—facilitates diverse downstream transformations including nucleophilic substitution, amide coupling, and cyclization reactions. The compound exhibits bench stability and is readily purified by standard techniques, supporting its utility in high-throughput medicinal chemistry campaigns and process development workflows.

General Information

CAS No. 1192711-37-7
Cat. No. CS-0035791
Purity ≥95%
MDL No. MFCD24499915
Storage 4°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₈ClN₃O₂
Molecular Weight 213.62
Synonym(s) 2-Chloro-4-(cyclopropylamino)-5-pyrimidinecarboxylic acid
SMILES O=C(C1=CN=C(Cl)N=C1NC2CC2)O

Computational Chemistry Data

TPSA 75.11
LogP 1.4025
H_Acceptors 4
H_Donors 2
Rotatable_Bonds 3

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Functional Group Carboxylic Acid

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Key Words

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2-Chloro-4-(cyclopropylamino)pyrimidine-5-carboxylic acid

CAS No. 1192711-37-7

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