(2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide

Name: (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 1197953-49-3
Cat. No. CS-0028081
Purity≥96%
MDL No.MFCD29477700

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

(2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide|CS-0028081

Structure of 1197953-49-3

Size

Price

Quantity

* Please select Quantity before adding items.

Description

This dimethylphosphine oxide features a 2,5-dichloropyrimidin-4-ylamino-substituted phenyl scaffold, delivering enhanced electronic tuning and steric bulk. The phosphine oxide moiety provides robust stability and facilitates coordination in transition metal catalysis. Its bench-stable nature enables straightforward handling in synthetic workflows.

Application

(2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide serves as a versatile building block in medicinal chemistry, enabling efficient construction of functionalized heterocycles via palladium-catalyzed cross-coupling. The dichloropyrimidine moiety provides high reactivity in nucleophilic substitution, while the dimethylphosphine oxide group offers excellent stability and compatibility with diverse reaction conditions. Its bench-stable nature and orthogonal reactivity facilitate streamlined synthesis of complex scaffolds relevant to kinase inhibitor development and other pharmaceutical applications.

General Information

CAS No. 1197953-49-3
Cat. No. CS-0028081
Purity ≥96%
MDL No. MFCD29477700
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₂H₁₂Cl₂N₃OP
Molecular Weight 316.12
Synonym(s) 4-(orthodimethylphosphinylanilino)-5-chloro-2-chloropyrimidine
SMILES O=P(C1=CC=CC=C1NC2=NC(Cl)=NC=C2Cl)(C)C

Computational Chemistry Data

TPSA 54.88
LogP 3.775
H_Acceptors 4
H_Donors 1
Rotatable_Bonds 3

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

1197953-49-3 sigma1197953-49-3 manufacturer1197953-49-3 price1197953-49-3 structure1197953-49-3 SDSbuy 1197953-49-31197953-49-3 supplier1197953-49-3 uses1197953-49-3 molecular weightprice of 1197953-49-31197953-49-3 chemical name formula of 1197953-49-3

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

(2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide

CAS No. 1197953-49-3

Recommended Products