(R)-3-Methoxypyrrolidine

Name: (R)-3-Methoxypyrrolidine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 120099-60-7
Cat. No. CS-0053757
Molecule weight101.15
Purity≥97%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 120099-60-7
Cat. No. CS-0053757
Purity ≥97%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₁₁NO
Molecular Weight 101.15
Synonym(s) None
SMILES CO[C@H]1CNCC1

Description

(R)-3-Methoxypyrrolidine is a chiral pyrrolidine derivative featuring a methoxy group at the 3-position, offering enhanced solubility and stability compared to unsubstituted analogs. This configuration provides stereochemical precision for applications in asymmetric synthesis, medicinal chemistry, and ligand design. The molecule integrates readily into complex scaffolds under standard conditions.

Application

(R)-3-Methoxypyrrolidine serves as a versatile chiral building block in medicinal chemistry, enabling stereoselective synthesis of bioactive molecules. Its pyrrolidine core provides a rigid, nitrogen-containing heterocyclic scaffold with favorable pharmacokinetic properties. The methoxy group at the 3-position offers enhanced solubility and metabolic stability, while the (R)-configuration ensures predictable stereochemical outcomes in coupling reactions. This compound exhibits excellent bench stability, facilitates efficient purification, and demonstrates broad functional group tolerance in standard synthetic transformations, making it ideal for API development and high-throughput screening campaigns.

Synthesis

Route1
- 672293-26-4
- ~77%
- In-stock
  
  120099-60-7
References
- Chakravarty, Sarvajit; Dugar, Sundeep; Lu, Qing; Luedtke, Gregory R.; Mavunkel, Babu J.; Perumattam, John J.; Tester, Richland W. Patent: US2004/142940 A1, 2004 ; Location in patent: Page/Page column 37 ; US 20040142940 A1
Route2
- 74-88-4
- ~%
- In-stock
  
  120099-60-7
- In-stock
  
  549532-08-3
References
- WO2006/19833 A1, ; Page/Page column 66 ; WO 2006/019833 A1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS02,GHS07
Signal Word : Danger	UN#: 1993
Class : 3	Packing Group : Ⅲ
Hazard Statements : H226-H315-H319-H335
Precautionary Statements : P210-P233-P240-P241-P242-P243-P280-P303+P361+P353-P370+P378-P403+P235-P501

Quality Control

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Computational Chemistry Data

TPSA 21.26
LogP -0.0053
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Key Words

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(R)-3-Methoxypyrrolidine

CAS No. 120099-60-7

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