4-Chloro-2-fluoroaniline

Name: 4-Chloro-2-fluoroaniline
Brand: ChemScene
Availability: InStock
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CAS No. 57946-56-2
Cat. No. CS-W014353
Purity≥98%
MDL No.MFCD00010625

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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Structure of 57946-56-2

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Description

4-Chloro-2-fluoroaniline features a fluorine atom at the ortho position relative to the amino group, enhancing electronic effects and metabolic stability. This electron-deficient aromatic scaffold integrates readily into pharmaceutical intermediates and agrochemicals. The chloro substituent provides a handle for further functionalization via cross-coupling reactions. Bench-stable and moisture-tolerant, it supports efficient synthesis under standard conditions.

Application

4-Chloro-2-fluoroaniline serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient access to substituted aromatic scaffolds. Its ortho-fluoro and para-chloro substituents provide enhanced metabolic stability and directed reactivity in cross-coupling and electrophilic substitution reactions. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for multi-step synthetic sequences and scale-up applications.

General Information

CAS No. 57946-56-2
Cat. No. CS-W014353
Purity ≥98%
MDL No. MFCD00010625
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₅ClFN
Molecular Weight 145.56
Synonym(s) 2-fluoro-4-chloroaniline
SMILES C1=C(C(=CC=C1Cl)N)F

Computational Chemistry Data

TPSA 26.02
LogP 2.0613
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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4-Chloro-2-fluoroaniline

CAS No. 57946-56-2

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