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Structure of 1201187-18-9
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6-Chloro-4-(trifluoromethyl)nicotinonitrile features a trifluoromethyl group and a nitrile moiety positioned ortho to a chlorine substituent on a pyridine ring, enabling selective functionalization in medicinal chemistry. The electron-deficient core supports efficient coupling reactions under mild conditions, offering high stability during synthesis and handling.
6-Chloro-4-(trifluoromethyl)nicotinonitrile serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles via palladium-catalyzed cross-coupling reactions. Its trifluoromethyl and nitrile groups provide strong electron-withdrawing character, enhancing reactivity in nucleophilic substitution and facilitating downstream functionalization. The chloro substituent offers a reliable handle for further derivatization, while the molecule exhibits good bench stability and compatibility with standard synthetic protocols.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: