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Structure of 1201657-24-0
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4-Chloro-5-(trifluoromethyl)pyrimidin-2-amine features a trifluoromethyl group that enhances metabolic stability and lipophilicity, while the chloro substituent enables facile cross-coupling. This electron-deficient pyrimidine scaffold integrates readily into pharmaceutical intermediates, particularly in kinase inhibitor development and agrochemical design.
4-Chloro-5-(trifluoromethyl)pyrimidin-2-amine serves as a versatile building block in medicinal chemistry, enabling efficient construction of heterocyclic scaffolds through palladium-catalyzed cross-coupling reactions. Its chloro group facilitates reliable C–C and C–N bond formation, while the trifluoromethyl moiety enhances metabolic stability and lipophilicity. The amine functionality offers direct access to diverse analogs via acylation, alkylation, or further functionalization, making it ideal for rapid lead optimization in drug discovery programs.
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GHS Pictogram :
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GHS No : GHS05,GHS07
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Signal Word : Danger
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UN#: 1759
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Class : 8
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Packing Group : Ⅲ
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Hazard Statements : H302-H318
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Precautionary Statements : P264-P270-P280-P330-P501
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Lot numbers can be found on the outside label of a product: