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CS-W001157 4
Total: USD 88.00

1-Phenylcyclobutanamine hydrochloride

  • CAS No. 120218-45-3

  • Cat. No. CS-W021366
  • Purity≥98%
  • MDL No.MFCD07838486
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

1-Phenylcyclobutanamine hydrochloride|CS-W021366

Structure of 120218-45-3

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Description

1-Phenylcyclobutanamine hydrochloride features a rigid cyclobutane scaffold bearing a primary amine and phenyl group, delivering enhanced metabolic stability compared to linear analogs. This bench-stable salt form ensures reliable handling and solubility in aqueous systems, enabling direct incorporation into medicinal chemistry campaigns targeting CNS-directed therapeutics and receptor modulators.

Application

1-Phenylcyclobutanamine hydrochloride serves as a valuable chiral building block for medicinal chemistry, enabling the synthesis of bioactive scaffolds through standard amine functionalization. Its cyclobutane core provides conformational rigidity beneficial for structure-activity studies, while the hydrochloride salt ensures excellent bench stability and ease of handling. The compound readily participates in nucleophilic substitution, reductive amination, and coupling reactions, facilitating efficient access to diverse heterocyclic and peptide-like architectures under routine laboratory conditions.

General Information

  • CAS No. 120218-45-3
  • Cat. No. CS-W021366
  • Purity ≥98%
  • MDL No. MFCD07838486
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₄ClN
  • Molecular Weight 183.68
  • Synonym(s) 1-Phenylcyclobutylamine hydrochloride
  • SMILES NC1(C2=CC=CC=C2)CCC1.[H]Cl

Computational Chemistry Data

  • TPSA   26.02
  • LogP   2.4463
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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