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Structure of 1202578-27-5
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cis-4-(Trifluoromethyl)cyclohexanecarboxylic acid features a rigid, electron-deficient cyclohexane ring with a polar carboxylic acid group positioned cis to the trifluoromethyl substituent. This stereochemistry enhances its lipophilic character and metabolic stability, making it valuable for medicinal chemistry applications requiring precise spatial orientation and resistance to oxidative degradation in bioactive scaffolds.
cis-4-(Trifluoromethyl)cyclohexanecarboxylic acid serves as a valuable chiral building block in medicinal chemistry, offering a rigid, lipophilic scaffold with enhanced metabolic stability. The carboxylic acid functionality enables direct derivatization into amides, esters, or acyl chlorides, while the cis-configured trifluoromethyl group imparts favorable conformational bias and improved membrane permeability. Its bench-stable nature and compatibility with standard coupling protocols make it well-suited for parallel synthesis and API development workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H312-H315-H319-H332-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: