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CS-W001157 4
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4-(Difluoromethoxy)pyridin-2-amine

  • CAS No. 1206972-19-1

  • Cat. No. CS-0198880
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-(Difluoromethoxy)pyridin-2-amine|CS-0198880

Structure of 1206972-19-1

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General Information

  • CAS No. 1206972-19-1
  • Cat. No. CS-0198880
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆F₂N₂O
  • Molecular Weight 160.12
  • Synonym(s) 4-(Difluoromethoxy)-2-pyridinamine
  • SMILES NC1=NC=CC(OC(F)F)=C1

Description

4-(Difluoromethoxy)pyridin-2-amine features a pyridin-2-amine core appended with a difluoromethoxy group at the 4-position, delivering enhanced electron-withdrawing character and metabolic stability. This substitution pattern imparts favorable solubility and compatibility with diverse synthetic transformations. The molecule integrates readily into bioactive scaffolds, particularly in medicinal chemistry applications targeting kinase inhibition and CNS-penetrant therapeutics.

Application

4-(Difluoromethoxy)pyridin-2-amine serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles through standard coupling reactions. Its difluoromethoxy group imparts enhanced metabolic stability and modulated lipophilicity, while the pyridin-2-amine moiety provides a robust handle for further functionalization via Suzuki-Miyaura, Buchwald-Hartwig, or electrophilic substitution. Bench-stable and readily purified, it functions effectively in multi-step syntheses targeting kinase inhibitors and CNS-active compounds.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   48.14
  • LogP   1.2652
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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