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Structure of 1206981-49-8
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3-(Trifluoromethoxy)pyridin-2-amine features a trifluoromethoxy group at the 3-position and an amino substituent at the 2-position of the pyridine ring, creating a unique electron-deficient heteroaryl scaffold. This configuration enables direct coupling in cross-coupling reactions and facilitates incorporation into bioactive molecules. The compound exhibits enhanced metabolic stability and lipophilicity compared to non-fluorinated analogs, making it valuable for medicinal chemistry applications.
3-(Trifluoromethoxy)pyridin-2-amine serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles through standard coupling reactions. Its trifluoromethoxy group enhances metabolic stability and lipophilicity, while the pyridin-2-amine moiety facilitates direct functionalization or transition-metal-catalyzed transformations. The compound exhibits good bench stability and is compatible with common purification methods, making it well-suited for iterative synthesis workflows in API development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: