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CS-W001157 4
Total: USD 88.00

3-(Difluoromethoxy)pyridin-2-amine

  • CAS No. 947249-14-1

  • Cat. No. CS-D0412
  • Purity≥97%
  • MDL No.MFCD12405788
  • HazMat Fee +

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

3-(Difluoromethoxy)pyridin-2-amine|CS-D0412

Structure of 947249-14-1

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Description

3-(Difluoromethoxy)pyridin-2-amine features a pyridine scaffold bearing a difluoromethoxy group at the 3-position and an amino function at the 2-position, delivering enhanced electron density and improved solubility in polar solvents. This configuration supports efficient coupling reactions and enables access to advanced intermediates in medicinal chemistry.

Application

3-(Difluoromethoxy)pyridin-2-amine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard coupling reactions. Its difluoromethoxy group imparts enhanced metabolic stability and modulated lipophilicity, while the pyridin-2-amine functionality facilitates efficient derivatization via Suzuki-Miyaura, Buchwald-Hartwig, or electrophilic substitution. The compound exhibits good bench stability and is readily purified by chromatography or crystallization, supporting scalable synthesis and integration into complex molecular architectures.

General Information

  • CAS No. 947249-14-1
  • Cat. No. CS-D0412
  • Purity ≥97%
  • MDL No. MFCD12405788
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆F₂N₂O
  • Molecular Weight 160.12
  • Synonym(s) 3-(Difluoromethoxy)-2-pyridinamine
  • SMILES NC1=NC=CC=C1OC(F)F

Computational Chemistry Data

  • TPSA   48.14
  • LogP   1.2652
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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