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CS-W001157 4
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5-Bromopyrazine-2-carbaldehyde

  • CAS No. 1211534-08-5

  • Cat. No. CS-0311024
  • Purity≥98%
  • MDL No.MFCD20275295

*For research and further manufacturing use only, not for direct human use.

5-Bromopyrazine-2-carbaldehyde|CS-0311024

Structure of 1211534-08-5

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General Information

  • CAS No. 1211534-08-5
  • Cat. No. CS-0311024
  • Purity ≥98%
  • MDL No. MFCD20275295
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃BrN₂O
  • Molecular Weight None
  • Synonym(s) 5-Bromo-2-pyrazinecarbaldehyde
  • SMILES O=CC1=NC=C(Br)N=C1

Description

5-Bromopyrazine-2-carbaldehyde features a brominated pyrazine core with a formyl group at the 2-position, enabling direct functionalization in cross-coupling and heterocyclic synthesis. This electron-deficient scaffold integrates readily into advanced pharmaceutical intermediates and materials precursors under standard conditions.

Application

5-Bromopyrazine-2-carbaldehyde serves as a versatile building block for the synthesis of pyrazine-based heterocycles, enabling efficient transition-metal-catalyzed coupling reactions. The aldehyde group facilitates direct functionalization via nucleophilic addition or condensation, while the bromine substituent supports palladium-catalyzed cross-coupling transformations. Its bench-stable nature and compatibility with diverse reaction conditions make it ideal for constructing complex scaffolds in medicinal chemistry and materials science applications.

Safety Information

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Computational Chemistry Data

  • TPSA   42.85
  • LogP   1.0516
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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