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Structure of 1211581-51-9
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2-(Difluoromethoxy)isonicotinic acid features a para-difluoromethoxy group on an isonicotinic acid scaffold, delivering enhanced lipophilicity and metabolic stability. This electron-withdrawing substitution improves bioavailability in medicinal chemistry applications. The compound serves as a key building block for pharmaceuticals targeting kinase pathways and exhibits robust bench stability under standard conditions.
2-(Difluoromethoxy)isonicotinic acid serves as a versatile building block for bioactive heterocycles and pharmaceutical intermediates, leveraging its ortho-difluoromethoxy-substituted pyridine core. The carboxylic acid functionality enables direct coupling reactions, while the difluoromethoxy group imparts metabolic stability and modulates electronic properties. This compound exhibits excellent bench stability, facilitates straightforward purification, and functions reliably in standard amide, ester, and Suzuki-Miyaura transformations.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: