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Structure of 1214385-82-6
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Methyl 6-bromo-2-fluoronicotinate is a fluorinated heterocyclic ester featuring strategic halogen substitution at the 6-position (bromine) and 2-position (fluorine). This combination imparts enhanced electrophilicity and directional reactivity, enabling efficient coupling in cross-coupling transformations. The methyl ester group provides a stable, handleable platform for downstream functionalization in synthetic organic chemistry and medicinal chemistry applications.
Methyl 6-bromo-2-fluoronicotinate serves as a versatile building block in medicinal chemistry and heterocyclic synthesis, enabling efficient late-stage functionalization via palladium-catalyzed cross-coupling reactions. The ortho-fluoro and bromo substituents offer complementary reactivity for sequential derivatization, while the methyl ester group supports straightforward manipulation. Bench-stable and readily purified by flash chromatography, it facilitates robust access to substituted nicotinates and complex scaffolds relevant to API development.
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GHS Pictogram :
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GHS No : GHS06
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Signal Word : Danger
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UN#: 2811
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H301-H311-H331
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361+P364-P405-P501
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Lot numbers can be found on the outside label of a product: