2-(5-Aminopyridin-2-yl)-2-methylpropanenitrile

Name: 2-(5-Aminopyridin-2-yl)-2-methylpropanenitrile
Brand: ChemScene
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CAS No. 1226776-95-9
Cat. No. CS-W003879
Purity≥98%
MDL No.MFCD16495866

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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2-(5-Aminopyridin-2-yl)-2-methylpropanenitrile|CS-W003879

Structure of 1226776-95-9

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Description

This nitrile features a 5-aminopyridin-2-yl group attached to a sterically hindered methylpropanenitrile scaffold, enabling efficient coupling in transition-metal-catalyzed transformations. The electron-rich pyridine ring enhances reactivity in cross-coupling protocols, while the bench-stable nitrile moiety simplifies handling and purification.

Application

2-(5-Aminopyridin-2-yl)-2-methylpropanenitrile serves as a versatile building block in medicinal chemistry, enabling the construction of pyridine-based scaffolds through standard coupling and functionalization reactions. Its nitrile group offers high stability and compatibility with diverse reaction conditions, while the ortho-aminopyridine moiety facilitates further derivatization via electrophilic substitution or metal-catalyzed cross-coupling. The tert-butyl nitrile functionality provides excellent bench stability and simplifies purification, making it well-suited for iterative synthesis workflows in API development.

General Information

CAS No. 1226776-95-9
Cat. No. CS-W003879
Purity ≥98%
MDL No. MFCD16495866
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₉H₁₁N₃
Molecular Weight 161.20
Synonym(s) 5-amino-α,α-dimethyl-2-Pyridineacetonitrile
SMILES CC(C#N)(C1=NC=C(N)C=C1)C

Computational Chemistry Data

TPSA 62.7
LogP 1.46498
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Cyanide/Nitrile

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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2-(5-Aminopyridin-2-yl)-2-methylpropanenitrile

CAS No. 1226776-95-9

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