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Structure of 405103-02-8
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6-Isopropylpyridin-3-amine features a pyridine core with strategically positioned isopropyl and primary amine groups, enabling robust coordination in catalytic systems. The electron-donating isopropyl moiety enhances nucleophilicity at the nitrogen center, while the sterically accessible amine facilitates efficient ligand integration in transition metal complexes. This structure supports stability under standard bench conditions and offers tunable reactivity for synthetic applications.
6-Isopropylpyridin-3-amine serves as a versatile building block in medicinal chemistry, enabling the synthesis of kinase inhibitors and other bioactive heterocycles. Its pyridine core provides a strong hydrogen-bond acceptor site, while the isopropyl group enhances lipophilicity and metabolic stability. The primary amine facilitates straightforward derivatization via acylation, alkylation, or coupling reactions, supporting rapid SAR exploration. Bench-stable and readily purified by chromatography or recrystallization, it functions efficiently in standard coupling protocols and multistep synthetic sequences.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: