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Structure of 1443288-79-6
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3-(Difluoromethyl)-1H-pyrazol-4-amine features a difluoromethyl group at the 3-position, enhancing metabolic stability and lipophilicity. The pyrazole core provides a rigid, electron-rich scaffold ideal for hydrogen bonding. This compound integrates readily into bioactive molecules, particularly in kinase inhibitors and agrochemicals, due to its balanced polarity and robustness under standard conditions.
3-(Difluoromethyl)-1H-pyrazol-4-amine serves as a valuable building block in medicinal chemistry, enabling the introduction of a polar, metabolically stable difluoromethyl group adjacent to a hydrogen-bond-donating amine. Its reactivity facilitates direct coupling and functionalization in standard synthetic workflows, with good bench stability and compatibility across diverse reaction conditions.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: