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Structure of 1251844-06-0
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This boronate ester features a sterically shielded tetramethyl-1,3,2-dioxaborolane core paired with a 3,5-difluoro-4-(trifluoromethyl)phenyl group. The electron-deficient aryl moiety enhances coupling efficiency in Suzuki-Miyaura reactions, while the bench-stable structure resists hydrolysis under standard conditions.
This boronate ester serves as a robust building block for Suzuki-Miyaura cross-coupling reactions, enabling efficient C–C bond formation under mild conditions. The trifluoromethyl and difluoro substituents confer enhanced metabolic stability and lipophilicity, making it particularly valuable in medicinal chemistry. Its tetramethyl-substituted dioxaborolane core ensures excellent bench stability, minimal protodeboronation, and ease of purification—ideal for scalable synthesis of complex fluorinated biaryls and heterocyclic scaffolds.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319
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Precautionary Statements : P264-P280-P302+P352-P362+P364
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Lot numbers can be found on the outside label of a product: