tert-Butyl 4-amino-3,3-difluoropiperidine-1-carboxylate

Name: tert-Butyl 4-amino-3,3-difluoropiperidine-1-carboxylate
Brand: ChemScene
Availability: InStock
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CAS No. 1255666-48-8
Cat. No. CS-W001365
Purity≥95%
MDL No.MFCD16250242

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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tert-Butyl 4-amino-3,3-difluoropiperidine-1-carboxylate|CS-W001365

Structure of 1255666-48-8

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Description

tert-Butyl 4-amino-3,3-difluoropiperidine-1-carboxylate features a sterically hindered piperidine core with dual fluorine atoms at the 3,3-position, enhancing metabolic stability and modulating electronic properties. The protected amine facilitates direct incorporation into complex scaffolds without side reactions, enabling streamlined synthesis of fluorinated bioactive molecules under standard conditions.

Application

tert-Butyl 4-amino-3,3-difluoropiperidine-1-carboxylate serves as a versatile building block in medicinal chemistry, enabling the construction of fluorinated piperidine scaffolds prevalent in bioactive molecules. The difluoromethylene group enhances metabolic stability and modulates electronic properties, while the tert-butyl carbamate provides orthogonal protection for amine functionalization. It exhibits excellent bench stability, facilitates straightforward deprotection under mild acidic conditions, and demonstrates compatibility with diverse coupling reactions, making it well-suited for iterative synthesis and high-throughput screening workflows.

General Information

CAS No. 1255666-48-8
Cat. No. CS-W001365
Purity ≥95%
MDL No. MFCD16250242
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₈F₂N₂O₂
Molecular Weight 236.26
Synonym(s) tert-butyl 4-amino-3,3-difluoropiperidin
SMILES O=C(N1CCC(C(C1)(F)F)N)OC(C)(C)C

Computational Chemistry Data

TPSA 55.56
LogP 1.5898
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 0

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Amine

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

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tert-Butyl 4-amino-3,3-difluoropiperidine-1-carboxylate

CAS No. 1255666-48-8

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