Cbz-NH-PEG1-CH2COOH

Name: Cbz-NH-PEG1-CH2COOH
Brand: ChemScene
Availability: InStock
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CAS No. 1260092-43-0
Cat. No. CS-0116294
Purity≥98%
MDL No.MFCD21933598

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HazMat Fee

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Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Structure of 1260092-43-0

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Description

Cbz-NH-PEG1-CH2COOH features a benzylcarbamate-protected amine linked to a single ethylene glycol unit, terminating in a carboxylic acid. This bifunctional scaffold enables site-specific conjugation in peptide synthesis and bioconjugation workflows, combining stability during storage with efficient deprotection under mild conditions.

Application

Cbz-NH-PEG1-CH2COOH serves as a versatile bifunctional linker for peptide and biomolecule conjugation. The Cbz group provides orthogonal protection for amines, while the PEG1 spacer enhances solubility and reduces aggregation. The terminal carboxylic acid enables direct coupling to amine-containing substrates via standard amide formation, facilitating efficient synthesis of bioconjugates with improved stability and handling properties.

General Information

CAS No. 1260092-43-0
Cat. No. CS-0116294
Purity ≥98%
MDL No. MFCD21933598
Storage -20°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₂H₁₅NO₅
Molecular Weight 253.25
Synonym(s) None
SMILES O=C(O)COCCNC(OCC1=CC=CC=C1)=O

Computational Chemistry Data

TPSA 84.86
LogP 1.014
H_Acceptors 4
H_Donors 2
Rotatable_Bonds 7

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Life Science PROTAC PROTAC Linker

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Proteolysis Targeting Chimera Research Reagents

Biochemistry Pharmaceutical Development and Drug Discovery Research Proteolysis Targeting Chimera Research Reagents

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Cbz-NH-PEG1-CH2COOH

CAS No. 1260092-43-0

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