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Structure of 126541-82-0
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Methyl 3-amino-4-(trifluoromethyl)benzoate features a trifluoromethyl group enhancing electron-withdrawal and metabolic stability, paired with a primary amine enabling facile derivatization. This aromatic ester integrates readily into synthetic routes for pharmaceutical intermediates, offering improved solubility and reactivity under standard conditions.
Methyl 3-amino-4-(trifluoromethyl)benzoate serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and pharmaceutical intermediates. The ortho-amino and trifluoromethyl groups provide strong electron-withdrawing and directing effects, facilitating palladium-catalyzed cross-couplings and cyclization reactions. Bench-stable and readily purified by chromatography or recrystallization, it functions efficiently in multi-step syntheses requiring selective functionalization.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: