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Structure of 127199-13-7
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(1R,2R)-2-Fluorocyclopropanecarboxylic acid features a rigid, strained cyclopropane ring with stereocontrolled fluorine substitution, delivering enhanced metabolic stability and conformational constraint. This configuration enables precise incorporation into bioactive molecules where steric and electronic effects are critical.
(1R,2R)-2-Fluorocyclopropanecarboxylic acid serves as a valuable chiral building block in medicinal chemistry, enabling the synthesis of fluorinated cyclopropyl-containing scaffolds. Its rigid cyclopropane ring imparts conformational constraint, while the carboxylic acid functionality facilitates direct derivatization into amides, esters, or acyl chlorides. The stereochemistry is stable under standard reaction conditions and supports orthogonal functional group transformations. This compound exhibits bench stability and ease of purification, making it well-suited for iterative synthetic campaigns in API development.
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GHS Pictogram :
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GHS No : GHS05,GHS07
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Signal Word : Danger
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UN#: 3261
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Class : 8
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Packing Group : Ⅱ
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Hazard Statements : H302-H314-H335
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Precautionary Statements : P260-P264-P270-P271-P280-P301+P330+P331-P304+P340-P363-P405-P501
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Lot numbers can be found on the outside label of a product: