(S)-Tert-Butyl 5-azaspiro[2.4]heptan-7-ylcarbamate

Name: (S)-Tert-Butyl 5-azaspiro[2.4]heptan-7-ylcarbamate
Brand: ChemScene
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CAS No. 127199-45-5
Cat. No. CS-W005356
Purity≥95%
MDL No.MFCD09955395

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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(S)-Tert-Butyl 5-azaspiro[2.4]heptan-7-ylcarbamate|CS-W005356

Structure of 127199-45-5

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Description

(S)-Tert-Butyl 5-azaspiro[2.4]heptan-7-ylcarbamate is a chiral spirocyclic scaffold featuring a constrained nitrogen-containing ring system and a bench-stable tert-butyl carbamate handle. This configuration enables direct incorporation into bioactive molecule libraries, particularly in medicinal chemistry campaigns targeting GPCRs and kinases, where stereocontrol and conformational rigidity are critical for potency and selectivity.

Application

(S)-Tert-Butyl 5-azaspiro[2.4]heptan-7-ylcarbamate serves as a stereochemically defined spirocyclic building block for medicinal chemistry, enabling efficient access to constrained piperidine-like scaffolds. Its tert-butyl carbamate group offers excellent bench stability and orthogonal deprotection, while the azaspiro core provides rigidity and defined spatial orientation, facilitating structure-activity relationship studies in CNS-targeted drug discovery.

General Information

CAS No. 127199-45-5
Cat. No. CS-W005356
Purity ≥95%
MDL No. MFCD09955395
Storage RT, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₁H₂₀N₂O₂
Molecular Weight 212.29
Synonym(s) tert-butyl (7S)-5-azaspiro[2.4]hept-7-ylcarbamate
SMILES O=C(OC(C)(C)C)N[C@@H]1CNCC21CC2

Computational Chemistry Data

TPSA 50.36
LogP 1.2631
H_Acceptors 3
H_Donors 2
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Pyrrolidine compounds

Building Blocks Skeleton Fatty ring compounds Cyclopropane compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Building Blocks Skeleton Spirol Rings compounds

Key Words

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(S)-Tert-Butyl 5-azaspiro[2.4]heptan-7-ylcarbamate

CAS No. 127199-45-5

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