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Structure of 128562-95-8
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4-(Trifluoromethyl)-1H-indole features a trifluoromethyl group at the 4-position of the indole core, enhancing electron deficiency and metabolic stability. This moiety integrates readily into bioactive scaffolds, offering improved membrane permeability and resistance to oxidative degradation in medicinal chemistry applications.
4-(Trifluoromethyl)-1H-indole serves as a valuable building block in medicinal chemistry, enabling direct incorporation of a strongly electron-withdrawing trifluoromethyl group at the C4 position of the indole core. Its stability and compatibility with diverse reaction conditions facilitate functionalization at multiple sites, particularly in cross-coupling and electrophilic substitution reactions. The molecule functions as a key scaffold for bioactive heterocycles and offers enhanced metabolic stability in drug candidates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P260-P264-P270-P271-P280-P301+P310-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: