2,4-Dichloro-7-nitroquinazoline

Name: 2,4-Dichloro-7-nitroquinazoline
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 129112-65-8
Cat. No. CS-0141014
Purity≥95%
MDL No.MFCD18157742

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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2,4-Dichloro-7-nitroquinazoline|CS-0141014

Structure of 129112-65-8

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Description

2,4-Dichloro-7-nitroquinazoline features a highly electron-deficient quinazoline core with dual chloro substituents at positions 2 and 4, enhancing reactivity for nucleophilic substitution. The para-nitro group at position 7 further increases electrophilicity, enabling efficient coupling in heterocyclic synthesis. This compound serves as a key scaffold for developing kinase inhibitors and advanced pharmaceutical intermediates under standard bench conditions.

Application

2,4-Dichloro-7-nitroquinazoline serves as a versatile building block in medicinal chemistry, enabling regioselective functionalization at the C2 and C4 positions via palladium-catalyzed cross-coupling reactions. Its electron-deficient quinazoline core enhances reactivity in nucleophilic substitution processes, while the nitro group provides a handle for reduction and downstream derivatization. The compound exhibits good bench stability and facilitates the construction of complex heterocyclic scaffolds relevant to kinase inhibitor development.

General Information

CAS No. 129112-65-8
Cat. No. CS-0141014
Purity ≥95%
MDL No. MFCD18157742
Storage -20°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₃Cl₂N₃O₂
Molecular Weight 244.03
Synonym(s) None
SMILES O=[N+](C1=CC2=NC(Cl)=NC(Cl)=C2C=C1)[O-]

Computational Chemistry Data

TPSA 68.92
LogP 2.8448
H_Acceptors 4
H_Donors 0
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Other Classifications

Building Blocks Functional Group Nitro compounds

Building Blocks Skeleton Aromatic heterocycle compounds Quinazoline compounds

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2,4-Dichloro-7-nitroquinazoline

CAS No. 129112-65-8

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