4-(2,2,2-Trifluoroethyl)aniline

Name: 4-(2,2,2-Trifluoroethyl)aniline
Brand: ChemScene
Availability: InStock
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CAS No. 131395-17-0
Cat. No. CS-0060246
Purity≥97%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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4-(2,2,2-Trifluoroethyl)aniline|CS-0060246

Structure of 131395-17-0

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Description

4-(2,2,2-Trifluoroethyl)aniline features a trifluoromethylated ethyl linker that enhances lipophilicity and metabolic stability while maintaining amine reactivity. This electron-rich aniline derivative serves as a key scaffold in bioactive molecule synthesis, particularly for pharmaceutical intermediates requiring enhanced membrane permeability and resistance to oxidative degradation under standard bench conditions.

Application

4-(2,2,2-Trifluoroethyl)aniline serves as a versatile building block in medicinal chemistry, enabling the introduction of a lipophilic trifluoromethyl-containing alkyl chain at the para position of an aromatic amine. The molecule exhibits good bench stability and functional group tolerance, facilitating downstream transformations such as Suzuki-Miyaura coupling, reductive amination, or amide formation. Its synthetic utility is well-documented in the construction of bioactive heterocycles and API scaffolds requiring enhanced metabolic stability and membrane permeability.

General Information

CAS No. 131395-17-0
Cat. No. CS-0060246
Purity ≥97%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₈F₃N
Molecular Weight 175.15
Synonym(s) None
SMILES C1=C(C=CC(=C1)N)CC(F)(F)F

Computational Chemistry Data

TPSA 26.02
LogP 2.3736
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H319
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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4-(2,2,2-Trifluoroethyl)aniline

CAS No. 131395-17-0

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