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CS-W001157 4
Total: USD 88.00

2-(4-Bromophenyl)piperidine

  • CAS No. 383128-14-1

  • Cat. No. CS-0132036
  • Molecule weight240.14
  • Purity≥98%
  • MDL No.MFCD02663580

*For research and further manufacturing use only, not for direct human use.

2-(4-Bromophenyl)piperidine|CS-0132036

Structure of 383128-14-1

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General Information

  • CAS No. 383128-14-1
  • Cat. No. CS-0132036
  • Purity ≥98%
  • MDL No. MFCD02663580
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₄BrN
  • Molecular Weight 240.14
  • Synonym(s) 2-(4-Bromophenyl)piperidine hemioxalate
  • SMILES BrC1=CC=C(C2NCCCC2)C=C1

Description

2-(4-Bromophenyl)piperidine is a versatile intermediate featuring a brominated phenyl ring fused to a piperidine core. This structure enables direct functionalization in cross-coupling reactions, offering efficient access to bioactive compounds. The electron-deficient aryl group enhances reactivity in palladium-catalyzed transformations, while the nitrogen-bearing heterocycle supports diverse derivatization pathways.

Application

2-(4-Bromophenyl)piperidine serves as a versatile building block in medicinal chemistry, enabling the construction of diverse heterocyclic scaffolds through standard coupling reactions. Its brominated aryl group facilitates palladium-catalyzed cross-coupling transformations, while the piperidine core provides a basic nitrogen for derivatization. The compound exhibits good bench stability and is compatible with common purification methods, making it well-suited for iterative synthesis workflows in API development.

Synthesis

  • Route1
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    • In-stock
      2-(4-Bromophenyl)piperidine|CS-0132036
      383128-14-1

    References

    • Boivin, Jean; Pothier, Julien; Zard, Samir Z. Tetrahedron Letters, 1999 , vol. 40, # 19 p. 3701 - 3704
  • Route2
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      226920-46-3
    • ~%
    • In-stock
      2-(4-Bromophenyl)piperidine|CS-0132036
      383128-14-1

    References

    • Boivin, Jean; Pothier, Julien; Zard, Samir Z. Tetrahedron Letters, 1999 , vol. 40, # 19 p. 3701 - 3704

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   12.03
  • LogP   3.2637
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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