4-Methylbenzoic anhydride

Name: 4-Methylbenzoic anhydride
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CAS No. 13222-85-0
Cat. No. CS-W022217
Purity≥95%
MDL No.MFCD00048100

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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Structure of 13222-85-0

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Description

4-Methylbenzoic anhydride delivers a reactive acylating moiety for efficient amide bond formation. The para-methyl group enhances electron density at the carbonyl, improving reactivity while maintaining bench-stable handling. This anhydride integrates readily into synthetic workflows requiring selective derivatization of amines and alcohols under mild conditions.

Application

4-Methylbenzoic anhydride serves as a versatile acylating agent in synthetic organic chemistry, enabling efficient ester and amide formation under mild conditions. Its benzylic methyl group enhances stability and facilitates purification, while the aromatic anhydride core exhibits high reactivity toward nucleophiles. This reagent functions reliably in standard bench-scale transformations, including peptide coupling and heterocycle functionalization, offering predictable yields and minimal side reactions.

General Information

CAS No. 13222-85-0
Cat. No. CS-W022217
Purity ≥95%
MDL No. MFCD00048100
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₆H₁₄O₃
Molecular Weight 254.28
Synonym(s) P-TOLUIC ANHYDRIDE
SMILES O=C(OC(C1=CC=C(C)C=C1)=O)C2=CC=C(C)C=C2

Computational Chemistry Data

TPSA 43.37
LogP 3.30064
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 2

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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4-Methylbenzoic anhydride

CAS No. 13222-85-0

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