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Structure of 132606-40-7
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5-Bromo-2-chloro-6-methylpyridine features a halogenated pyridine core with complementary reactivity at the 5-bromo and 2-chloro positions, enabling selective cross-coupling. The methyl group enhances solubility and electronic modulation, while the bench-stable structure supports reliable use in transition-metal-catalyzed transformations.
5-Bromo-2-chloro-6-methylpyridine serves as a versatile building block in medicinal chemistry and heterocyclic synthesis, enabling palladium-catalyzed cross-coupling reactions due to its complementary halogenation pattern. The bromo group facilitates efficient coupling with boronic acids, while the chloro functionality offers orthogonal reactivity under selective conditions. Its methyl group enhances lipophilicity and provides a handle for further functionalization. Bench-stable and readily purified by distillation or chromatography, it functions reliably in multistep syntheses of pyridine-based pharmaceutical intermediates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: