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Structure of 133232-58-3
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4-Iodo-2-methylbenzoic acid features a sterically hindered ortho-methyl group paired with a para-iodo substituent, enhancing its utility in palladium-catalyzed cross-coupling reactions. The carboxylic acid moiety enables direct derivatization, while the iodine handle facilitates efficient functionalization under standard conditions.
4-Iodo-2-methylbenzoic acid serves as a versatile building block in cross-coupling reactions, enabling efficient C–C bond formation via palladium-catalyzed methodologies. Its iodine handle provides high reactivity in Suzuki, Stille, and Negishi couplings, while the carboxylic acid and methyl groups offer orthogonal functionalization potential. The compound exhibits excellent bench stability and is readily purified by recrystallization, making it ideal for iterative synthesis of complex pharmaceutical intermediates and heterocyclic scaffolds.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: