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CS-W001157 4
Total: USD 88.00

N-Benzylcyclopropylamine

  • CAS No. 13324-66-8

  • Cat. No. CS-0156270
  • Purity≥96%
  • MDL No.MFCD00089909

*For research and further manufacturing use only, not for direct human use.

N-Benzylcyclopropylamine|CS-0156270

Structure of 13324-66-8

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General Information

  • CAS No. 13324-66-8
  • Cat. No. CS-0156270
  • Purity ≥96%
  • MDL No. MFCD00089909
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₃N
  • Molecular Weight None
  • Synonym(s) N-Cyclopropyl-benzylamine
  • SMILES C1=CC=C(C=C1)CNC2CC2

Application

N-Benzylcyclopropylamine serves as a valuable building block in medicinal chemistry, enabling the construction of bioactive heterocycles and conformationally restricted scaffolds. Its cyclopropyl ring imparts unique stereoelectronic properties, while the benzyl group enhances lipophilicity and provides a handle for further functionalization. The amine functionality facilitates straightforward derivatization via alkylation, acylation, or reductive amination, offering robust utility in lead optimization campaigns.

Synthesis

  • Route1
    • null|null
      100-39-0
    • null|null
      765-30-0
    • ~47%
    • In-stock
      N-Benzylcyclopropylamine|CS-0156270
      13324-66-8

    References

    • Nicolaou; Mathison, Casey J. N.; Montagnon, Tamsyn Journal of the American Chemical Society, 2004 , vol. 126, # 16 p. 5192 - 5201
  • Route2
    • null|null
      88048-45-7
    • ~77%
    • In-stock
      N-Benzylcyclopropylamine|CS-0156270
      13324-66-8

    References

    • Grotjahn Journal of Heterocyclic Chemistry, 1983 , vol. 20, # 4 p. 1031 - 1036
  • Route3
    • null|null
      3187-77-7
    • ~82%
    • In-stock
      N-Benzylcyclopropylamine|CS-0156270
      13324-66-8

    References

    • Nagasawa; Elberling; DeMaster Journal of Medicinal Chemistry, 1984 , vol. 27, # 10 p. 1335 - 1339

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2810
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.03
  • LogP   1.9386
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   3

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