trans-tert-Butyl ((1r,3r)-3-hydroxy-2,2,4,4-tetramethylcyclobutyl)carbamate

Name: trans-tert-Butyl ((1r,3r)-3-hydroxy-2,2,4,4-tetramethylcyclobutyl)carbamate
Brand: ChemScene
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CAS No. 1338812-41-1
Cat. No. CS-0054757
Purity≥95%
MDL No.MFCD20923769

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trans-tert-Butyl ((1r,3r)-3-hydroxy-2,2,4,4-tetramethylcyclobutyl)carbamate|CS-0054757

Structure of 1338812-41-1

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Description

trans-tert-Butyl ((1r,3r)-3-hydroxy-2,2,4,4-tetramethylcyclobutyl)carbamate is a sterically hindered cyclobutane scaffold featuring a bench-stable carbamate protecting group and a chiral hydroxyl moiety. This configuration enables selective functionalization in asymmetric synthesis, particularly in the construction of complex polycyclic frameworks under mild conditions.

Application

trans-tert-Butyl ((1r,3r)-3-hydroxy-2,2,4,4-tetramethylcyclobutyl)carbamate serves as a sterically encumbered, bench-stable chiral building block for cyclobutane-based medicinal chemistry. The protected hydroxyl group enables selective functionalization, while the rigid trans-cyclobutane core imparts conformational constraint useful in target-directed synthesis. Its stability under standard reaction conditions facilitates downstream transformations, including cross-coupling and cyclization protocols.

General Information

CAS No. 1338812-41-1
Cat. No. CS-0054757
Purity ≥95%
MDL No. MFCD20923769
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₃H₂₅NO₃
Molecular Weight 243.34
Synonym(s) trans-tert-Butyl 3-hydroxy-2,2,4,4-(tetraMethyl)cyclobutylcarbaMate
SMILES O=C(OC(C)(C)C)N[C@H]1C(C)(C)[C@H](O)C1(C)C

Computational Chemistry Data

TPSA 58.56
LogP 2.3066
H_Acceptors 3
H_Donors 2
Rotatable_Bonds 1

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330

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Other Classifications

Building Blocks Functional Group Amine

Building Blocks Functional Group Alcohol

Building Blocks Skeleton Fatty ring compounds Cyclobutane compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

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Key Words

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trans-tert-Butyl ((1r,3r)-3-hydroxy-2,2,4,4-tetramethylcyclobutyl)carbamate

CAS No. 1338812-41-1

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