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Structure of 13440-07-8
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Bis(1-naphthyl)phosphine oxide features two naphthyl groups attached to a phosphine oxide core, delivering enhanced electron-withdrawing character and steric bulk. This structure supports stable coordination in transition metal catalysis, particularly in palladium- and nickel-mediated cross-coupling reactions. The molecule exhibits robust bench stability and tolerates moisture-sensitive processes.
Bis(1-naphthyl)phosphine oxide serves as a stable, bench-ready ligand in palladium-catalyzed cross-coupling reactions, enabling efficient C–C bond formation under mild conditions. Its sterically demanding naphthyl groups enhance catalyst longevity and promote high functional group tolerance, facilitating reproducible coupling of aryl halides and pseudohalides. The oxide functionality improves solubility and simplifies purification, making it well-suited for scalable synthesis and process development in pharmaceutical and materials chemistry.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: